The synaptic barrages during SWs were composed of a rich repertoire of sequential structures. We found that neurons that fired spikes frequently in SWs received transient synaptic inputs during SWs.
In these ex vivo preparations, hippocampal networks self-reorganize to emit spontaneous neuronal activity that resembles in vivo neuronal activity ( 19), which includes SWs with repeated spike sequences ( 20, 21). We used hippocampal slice cultures because they have low light scattering and provide a unique opportunity for high-speed, large-scale optical recordings of spontaneous calcium activity from hundreds of spines ( 11).
During SWs, the offline reactivation of spatial and episodic neuronal sequences is observed in the hippocampus ( 4– 7), and this reactivation contributes to memory consolidation ( 17) and neuronal homeostasis ( 18). In the present work, we investigated how the dendrites of CA1 pyramidal cells are spatiotemporally activated during spontaneous sharp-wave (SW) ripple oscillations.
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